Cerebrospinal Fluid in Health And in Disease

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Foam I found that all pathologic fluids produce a foam on shak- ing. When a test tube is filled one-third to one-half its size with fluid, and is shaken for two or three minutes, a heavy foam one to two inches in thickness forms, persist- ing for half an hour or longer. When normal fluid is shaken in a test tube only a thin foam forms, disappearing in a few minutes. The foam is present in all pathologic fluids, but it is of greater size and duration in acute infections of the meninges. Recently
... Zingher described the formation of a heavy foam in poliomyelitis which corroborates my observations. It seems but natural to think that the foam production is due to the C0 2 in the fluid. Close observa- tion, however, does not bear this out. I found repeatedly that a foam formed just as readily in fluid in which all the C0 2 had been driven off, if the fluid was pathologic. The foam, therefore, is best explained by the increased amount of protein in the fluid.
Cells Any infection of the meninges gives rise to an increased number of cells in the cerebrospinal fluid.


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