Chemical Basis of Pharmacology An Introduction to Pharmacodynamics Based On the

Cover Chemical Basis of Pharmacology An Introduction to Pharmacodynamics Based On the
Chemical Basis of Pharmacology An Introduction to Pharmacodynamics Based On the
Francis V. R.
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NH;H 1. CH 2 < ! +HC1 X CH 2 . CH 3 . JNH 2 2. One method used in the synthetic formation of pyridine deriva- tives is due to Hantzch, and consists in the condensation of /3-keto compounds (such as acetoacetic ester) with aldehydes and ammonia. An example of this condensation is seen in the following forma- tion of dihydro-collidine-dicarboxylic ester by the interaction of acetaldehyde, ammonia, and acetoacetic ester CH 3 CH A- H 2 C 2 H 6 OOC. CiH HiC. COOCoH ;.

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