Cumulative Effects of Bupivacaine Epidural Anesthesia And Obstetric Variables On Neonatal Behavior

Cover Cumulative Effects of Bupivacaine Epidural Anesthesia And Obstetric Variables On Neonatal Behavior
Cumulative Effects of Bupivacaine Epidural Anesthesia And Obstetric Variables On Neonatal Behavior
Sepkoski, Carol Marie
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studies, a multiple regression design was used to tease out the interaction of the variables and to investigate the variables which contributed to different behaviors. In order to avoid the problems of weighting different drugs, no medication for pain relief other than bupivacaine epidural anesthesia was included. The dose and time of administration were the only drug-related variables allowed to vary in the study. This choice of obstetric medication was made because bupivacaine epidurals are t
...he drug and route of administration most commonly used in the Boston maternity hospitals. Statistics for the United States and Great Britain have indicated that it is used in at least 40% of all deliveries (Plumer, 1978; Reynolds, Hargrove & Wyman, 1973) .
Bupivacaine has become the agent of choice for epidural deliveries because it has a greater potency and a longer duration of action than other local anesthetics. It also has the greatest plasma protein binding capacity and is highly lipid soluble (Covino, 1971).


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