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Ethical Procedures in Comparative Evaluation of Drugs

Cover Ethical Procedures in Comparative Evaluation of Drugs
Ethical Procedures in Comparative Evaluation of Drugs
O E Percus
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However, we will concen- trate our attention in this lecture on the 3=0 regime, and hence on the total mean failures C Since our procedure, like any other, is most effective in the extreme case p = 1, p = 0, a sensible analysis should focus on the penalty exacted by non-vanishing values q A a and P R • For this purpose, we may rewrite (61) as 3 3 P - P 1 - P 2 ABab A-l, Bab ABa, b-l = 6 ABab, 0000 + q A (P AB, a-l, b P A-l, Bab ) 2 2 + P B (P A, B-l, ab " P ABa, b-l and carry out an expansion w...ith respect to q and p . This is not trivial, due to non-constant coefficients , X and P 2 expansion is already known, since (77) expands out to implicit in P and P . Of course, part of the q, p_, A B , ^b+2 t - Xq A = Ap A t t (A) -> as A -> (79) C J°'PB> =

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