General Chemistry of the Enzymes

Cover General Chemistry of the Enzymes
General Chemistry of the Enzymes
Hans Von Euler
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That the process is a relatively rapid one has been shown by P a w 1 o w and his collaborators.
In one way or another, the zymogen is often activated " spontaneously/' In most cases the substrate or some foreign substance succeeding it yields the activator as the result of a slow reaction of some kind. In an interesting investigation H o y e r (loc. Cit. ) observed the appearance of lactic acid as such an activating substance. If the activator is a normal product of the substrate under the give
...n conditions, the well-known case of auto-catalysis presents itself. A typical example of such a reaction is the spontaneous decomposition of ethyl acetate in aqueous solution; in this instance the liberated acetic acid is the catalyst which accelerates the subsequent hydrolysis in proportion to the concentration of its hydrogen ions.
Meanwhile there are no grounds for making an essential distinction between the activation of the zymogen with initiation of the reaction and the action of acids, alkalis and many salts in accelerating the reaction.


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