Heredity Disease And Human Evolution

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But such a method will always remain extremely uncertain.
A second conceivable possibility is that the germs de- rived from the respective parents are unsuitable to one another, and that this unsuitability leads to disturbances in the act of fertilisation. This is a possibility which has often been mooted, but the attainment of secure principles is here hardly possible. It is merely a hypothetical ex- planation, proposed in the' lack of something better.
In the third place it is necessary to po
...int out that the origination of diseases de novo may well be apparent merely. There is no doubt that germinal anomalies may remain latent for generations, and only manifest themselves again when circumstances arise specially favourable to their appearance. If the former occurrence of these pathologi- cal states has been forgotten, they are supposed to have originated de novo. There can be no doubt that such obliv- ion plays a large part in the explanation. We are led to see this by the simple consideration that none of the morbid states to-day observed to be hereditary made their first appearance in the times in which we now live.

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