Immune Sera; a Concise Exposition of Our Present Knowledge of Infection And Immunity

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C II shows the condition of unchanged affinity.
In this case, if we add the bacterium to the mixture I30 IMMUNE SERA of complement and excess of inter-body, all the receptors of the bacterium will, to be sure, be occu- pied by inter-bodies, but this will be entirely with- out regard to the fact that these inter-bodies are or are not loaded with complement. It may there- fore happen that only a few of the bacterial receptors will be occupied by complemented (i.e., active) inter-bodies, while the
... rest of the bacterial receptors are occupied by uncomplemented (hence inactive) inter-bodies. As already stated, however, the vitality of such a bacterium is not necessarily destroyed.
D II represents the last conceivable case. It i« assumed that the " completion " of the inter-body has resulted in a diminution of the latter's affinity for the bacterial receptor. In this case primarily only the uncomplemented inter-bodies will com- bine with the bacterial receptors, while the free fluid will contain complemented inter-bodies ; In cases C II and D II, therefore, the excess of inter-body exerts a deflecting action on the complement, thus diminishing the end results.


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