Infection And Immunity a Text book of Immunology And Serology for Students And

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Collectively those substances which are capable of rendering an animal anaphylactic are spoken of as anaphyladogens, allergens, or sensibilisinogens .
Serum Sickness. It was next shown that any animal may be rendered anaphylactic, but that the mode and intensity of the reaction is not the same in all. The most susceptible animal is evidently the guinea-pig, and we have already seen the manner in which it reacts to the introduction of horse serum. In man the same antigen leads to those symptoms
...which collectively are spoken of as serum sickness, the most common of which are the occurrence of fever, of exanthemata, and of swelling of the joints. In dogs we note great restlessness, crying out aloud, and marked fall in blood- pressure, non-coagulability of the blood, and leukopenia. In goats extreme myosis has been observed.
Passive Anaphylaxis. Most important further is the observation that the anaphylactic reaction product (the anaphylactin or sensi- PRODUCTION OF THE ANAPHYLACTIC SHOCK 155 bilisin of the French; the allergin of v.


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