Laboratory Guide in Experimental Pharmacology
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doses while others require 5 cc.) Note the marked change in respiration which occurs be- fore the convulsions come on.
It will be seen that the convulsions caused by thujon are also of a distinctly different type from those following a poisonous dose of strychnine. Those caused by the latter drug are tonic in type and are due to an action on the spinal EXPERIMENTAL PHARMACOLOGY 113 ij^ LABORATORY GUIDE IN EXPERIMENTAL PHARMACOLOGY 115 cord. On the other hand, the thujon (and camphor) con- vulsi...ons are "clonic" and are caused by stimulation of some unknown part of the cerebrum or lower part of the brain.
Picrotoxin, the active principle of a climbing shrub, Anamirta paniculata, indigenous to India, also has a phar- macological action much like the drugs mentioned above, and the clonic type of convulsion may be very easily dem- onstrated by its use.
II. Inject into a frog i mg. picrotoxin and replace the animal under the bell jar. When the convulsions come on study them carefully indicating by a drawing the position the animal takes.
What to read after Laboratory Guide in Experimental Pharmacology?
You can find similar books in the "Read Also" column, or choose other free books by C W Charles Wallis Edmunds to read onlineMoreLess
To quickly assess the difficulty of the text, read a short excerpt:
doses while others require 5 cc.) Note the marked change in respiration which occurs be- fore the convulsions come on.
It will be seen that the convulsions caused by thujon are also of a distinctly different type from those following a poisonous dose of strychnine. Those caused by the latter drug are tonic in type and are due to an action on the spinal EXPERIMENTAL PHARMACOLOGY 113 ij^ LABORATORY GUIDE IN EXPERIMENTAL PHARMACOLOGY 115 cord. On the other hand, the thujon (and camphor) con- vulsi...ons are "clonic" and are caused by stimulation of some unknown part of the cerebrum or lower part of the brain.
Picrotoxin, the active principle of a climbing shrub, Anamirta paniculata, indigenous to India, also has a phar- macological action much like the drugs mentioned above, and the clonic type of convulsion may be very easily dem- onstrated by its use.
II. Inject into a frog i mg. picrotoxin and replace the animal under the bell jar. When the convulsions come on study them carefully indicating by a drawing the position the animal takes.
What to read after Laboratory Guide in Experimental Pharmacology?
You can find similar books in the "Read Also" column, or choose other free books by C W Charles Wallis Edmunds to read onlineMoreLess
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