Life of Elie Metchnikoff 1845 1916

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This was proved by a whole series of observations and by the fact that the immunity of higher animals is connected with an intense phagocytosis. In fact, as he ascended the scale of beings and studied their natural and artificial immunity, he ascertained that, in all of them, the essence of immunity, masked by the complexity of the organism, reduced itself to the phagocytes becoming accustomed to noxious agents. The mechan- ism of immunity in protozoa could therefore really be compared with tha...t of immunity in multicellular beings.
Becoming accustomed and becoming immune are phenomena of a general order, for they can be mani- fested not only by animals, but also by plants. They, too, have to defend themselves against numerous diseases. Lower vegetables, such as myxomycetes (beings which stand on the limit between the animal and vegetable kingdoms), have an amo3boid phase, in which they are but a simple heap of formless protoplasm. During that stage of their life, myxo- mycete behave towards noxious agents exactly in the same way as unicellular beings and, like them, acquire immunity by becoming gradually accustomed.


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