On the Nature of the Granule Cells of Paneth in the Intestinal Glands of Mammals

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The distribution of the cells of Paneth in the opossum absolutely ex- cludes the possibility of the cells of Paneth being young mucous cells, and equally opposed to this view are the facts brought out by Nicolas, Holier, and the writer, as to the indications of active secretion in the structure of the cells and as to their response to physiological stimulation. The cells of Paneth of the guinea pig respond to physiological stimulus of food by secretion as indicated by changes in the form of the... cell and reduction in the number and size of the granules. The crescent-shaped granules of Nicolas and others are due to im- perfect fixation and have no previous existence in the cell. Sidney Klein 329 It seems clear from these facts that the cells of Paneth are specific elements engaged in the secretion of a special substance, probably an enzyme which is of use in digestion. It is not, however, possible to con- nect the Paneth cells with the formation of the new substances, secretin, erepsin, and enterokinase, because these substances are also found in the small intestine of carnivora in which Paneth cells do not occur.

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