On the Production And Suppression of Muscular Twitchings And Hypersensitiveness

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But as only a few experiments were made with NagSO^ and NaCHOg, it is possible that a continuation of the work might lead to positive results.
It is, therefore, obvious that the centers can be caused to beat through a diminu- tion of the amount of Ca they contain, and it may be further argued that the presence of Ca in the sea-water is the cause, or at least one of the causes, that prevent the centers from beating in sea-water.
It should, however, be added that, while a certain diminution of Ca
... in the center is necessary for the development of rhythmical contractions, the diminution has its limit. It appears that, if too much Ca is removed from the tissues, the beats will also cease. This is demonstrated by the following facts: When we put the center of a medusa into sea-water to which enough sodium citrate has been added, beats begin at once, last for a certain time, and then cease. If at this time the centers are put back into sea-water with less or no sodium citrate, beats will begin again.

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