Ptomaïns, Leucocomaïns, Toxins And Antitoxins: Or, the Chemical Factors in the Causation of Disease

Victor C Victor Clarence Vaughan

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We have, there- fore, at least two well-defined sources of guanin, the nucleins and vernin.
Neither adenin nor guanin occurs in normal muscle fiirther than in mere traces, a fact which can only be explained on the ground that the muscle-tissue is poor in nucleated cells, and hence in nuclein. Just as the muscle-cell has become morphologically differentiated from the typical cell, it may be looked upon also as having undergone a concomitant chemical difierentiation, inasmuch as we no longer find... the phosphoric acid, xanthin, and hypoxanthin in the same chemical com bination as they occur in the original cell. The phosphoric acid, instead of existing as a part of an organic compound, is present in the muscle-tissue as a salt ; similarly the hypo- xanthin and xanthin occur in the free condition, extractable by water, and no longer in combination with other groups of atoms constituting a part of a more complex molecule — nuclein.
Guanin and creatin apparently mutually replace one an- other.

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