T Pa And Other Research Contributions At Genentech Oral History Transcript 2

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T Pa And Other Research Contributions At Genentech Oral History Transcript 2
Diane Pennica
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So we took a number of primary human colon tumors and found that, in fact, in the majority of them, the DNA copy number was about two fold in 60 percent of the primary human colon tumors that we looked at. It wasn t very dramatic, but it was at least two-fold. People sometimes don t get excited about two fold, but I remind them that if your temperature is elevated two-fold, you die.
55 Hughes: Yes. Good analogy.
Pennica: Another thing that you have to do in any project is determine once you fin
...d out that this might be a target for cancer, you have to find out where else in your body it s made. And if it s made everywhere in normal tissue, that s not a good thing because it means that it probably has a role and a function there, so if you try to inhibit its activity you could mess up something critical.
It was expressed in a number of normal human tissues, but it was significantly over- expressed, or elevated, in human colon tumors. About 84 percent of human colon tumors we looked at had elevated levels of WISP- 1.


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