The Croonian Lectures On the Chemical Side of Nervous Activity, Delivered Before the Royal College of Physicians of London, in June, 1901

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These chemical changes in the brain substance are. demonstrable by experiments with * Full details of all these experiments and observations will be shortly, published in a paper by Dr. Mott and myself in the forthcoming volume (vol. ii.) of Mott's Archives of Neurology.' CHEMICAL SIDE OF NERVOUS ACTIVITY 47 saline extracts of that tissue, or with the "surviving" brain of animals just killed. They are coincident with the histo- logical (chromatolytic) changes in nerve-cells, which can be ren- d...ered evident by the use of the methylene-blue method. The expression coagulation necrosis employed by Marinesco for this appearance is therefore justifiable. Marinesco and others who have employed exclusively histological methods of research, have naturally failed to grasp the chemical meaning of their Pig. 4. — Section of spinal cord from a case of hyperpyrexia, the tempera- ture being 109° P. before death. The whole of the cells throughout the central nervous system showed a diiluse homogeneous staining with methy^ lene blue.

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