The Elimination And Toxicity of Caffein in Nephrectomized Rabbits

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30 p. M. , rabbit lying on its side, struggled occasionally, in a comatose condition, dyspnoea quite marked; 1. 35 p. M. , died.
Rabbit 816. Belgian hare, male; weight, 1, 765 grams.
May 21: 3. 35 p. M. , double nephrectomy, loss of blood slight, condition good after operation.
May 22: 10. 15 a. M. , temperature 101 F. , weight 1, 745 grams; 10. 50 a. M. , 25 cc of 2 per cent caffein injected subcutaneously; 11. 30 a. M. , reflexes markedly in- creased; 12. 20 p. M. , symptoms of caffein poison
...ing pronounced, rabbit very hyper- sensitive, responded with a tremor when touched, respiration increased in rate and depth; 1. 30 p. M. , rabbit hypersensitive, attitude normal; 2. 15 p. M. , paralysis of extremities, dyspnoaa, increased sensitiveness; 5 p. M. , condition unchanged.
May 3: 9 a. M. , found dead; cold and stiff.
Analysis of the results obtained in these two groups of experiments tends to show a somewhat decreased toxicity of caffein when given some time after the removal of the kidneys.


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