The Genetic And the Operative Evidence Relating to Secondary Sexual Characters

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Nussbaiun and Meisenheimer had found that transplantation of pieces of the testes, and even injection of testes extract, into castrated frogs caused an enlargement of the thumb-pads. Smith shows that this conclusion rests on uncritical evidence. At any rate, his own more carefully planned experiments extending over the year show that the results obtained by Nussbaum and by Meisenheimer may be accounted for on other grounds than the effect of the injection or implantation.
The following statemen
...t by Smith is not without interest, since it bears directly on an important question as to how internal secretions may produce their effects.
"The deduction, therefore, which has been unduly based on Nussbaum's experiments, that the testis of the frog contains an internal secretion, which, on being circulated in the blood, calls for the development of the secondary sexual characters, either with or without the mediation of the nervous system, is without experimental f oimdation The fact that the developmental cycle of the thumb depends for its normal course on the presence of normal living testicular tissue can be equally well explained on the theory that the testicular cells enter into a chain of metaboUc processes in the body which do not pursue their normal course in the absence of the testicular cells.


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