The Principles of Acidosis And Clinical Methods for Its Study

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Thirty grams of sodium bicarbonate were in- jected intravenously, the tension of the pulse diminished and after ten hours the blood pressure had fallen to 135 millimeters of mercury. Sixteen hours after the injec- tion, the secretion of urine commenced. Without the use of any additional bicarbonate, the amount of urine increased rapidly and a prompt recovery followed.
In another case, anuria had persisted for three days. Secretion of urine finally commenced eighteen hours after several injectio
...ns of bicarbonate, amounting in all to ninety grams. The lesions of the kidney were so ad- vanced that the normal pigments were entirely sup- pressed when the first specimen of urine was passed, the sample being water-clear. A second specimen a few THERAPY 57 hours later contained a trace of pigment and the third specimen was straw-colored. This patient made an un- interrupted recovery without any additional injections. In ascribing these results to the effect of bicarbon- ate, the most pertinent question that suggests itself is whether the anuria of these cases would not have yielded to injections of neutral salt solution or other therapy.

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