The Serum Diagnosis of Disease
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My own results in 625 control cases were all negative except in a single instance ; a negro with pernicious anaemia showed a prompt reaction with a dilution ofl:10. The patient had no remembrance of any continued febrile disease. I never tested his blood a second time nor made any experiments with higher dilutions. I think the chances are that I made some slip in technique.
Johnston in " many hundred non-typhoid cases" has never yet seen a positive reaction under conditions where typhoid past o...r present could be excluded.
The six per cent of positive reactions reported in cases other than typhoid are to be explained, I believe, partly by er- rors of technique, and partly by the existence of foci of more or less " healed" typhoid infection within the body, which react to the test as foci of " healed" tuberculosis react to tuberculin.
On the whole I am convinced that a positive reaction always means typhoid infection past or present, provided the test is properly performed. But we must never forget, as we are too apt to do, that a positive serum reaction even in dilutions of 1 : 800 may mean only the leavings of past typhoid infection, since Widal has seen such a reaction eight years after infec- tion.
What to read after The Serum Diagnosis of Disease?
You can find similar books in the "Read Also" column, or choose other free books by Richard C Richard Clarke Cabot to read onlineMoreLess
To quickly assess the difficulty of the text, read a short excerpt:
My own results in 625 control cases were all negative except in a single instance ; a negro with pernicious anaemia showed a prompt reaction with a dilution ofl:10. The patient had no remembrance of any continued febrile disease. I never tested his blood a second time nor made any experiments with higher dilutions. I think the chances are that I made some slip in technique.
Johnston in " many hundred non-typhoid cases" has never yet seen a positive reaction under conditions where typhoid past o...r present could be excluded.
The six per cent of positive reactions reported in cases other than typhoid are to be explained, I believe, partly by er- rors of technique, and partly by the existence of foci of more or less " healed" typhoid infection within the body, which react to the test as foci of " healed" tuberculosis react to tuberculin.
On the whole I am convinced that a positive reaction always means typhoid infection past or present, provided the test is properly performed. But we must never forget, as we are too apt to do, that a positive serum reaction even in dilutions of 1 : 800 may mean only the leavings of past typhoid infection, since Widal has seen such a reaction eight years after infec- tion.
What to read after The Serum Diagnosis of Disease?
You can find similar books in the "Read Also" column, or choose other free books by Richard C Richard Clarke Cabot to read onlineMoreLess
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