The Transmutation of Bacteria

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The Ba^. anthra^oidss, discovered by Andrewes and de- scribed by Bainbridge (1903), was distinguished from the true B. anthracis by slight differences in the appearance of gelatin and agar cultures, in rate of growth and in motility and by its non-virulence. The observations of Savage and MacConkey, already quoted, as to the frequency with which atypical colonies of some organisms occur on gelatin, shows how CH. VI] VARIATIONS IN VIRULENCE 93 misleading such a distinction may be, and in this ca
...se, more- over, the difference in the appearance of colonies on agar could by the adoption of certain precautions be entirely eliminated. The rate of growth of organisms is always subject to variation. Slight motility was therefore the only distin- guishing feature to which any importance could be attached, apart from the question of virulence. As regards the latter, experiments indicated that this property could be increased by passage. Nevertheless these observers regarded the dif- ference in virulence as sufficiently fundamental to justify their description of the organism as a new species quite dis- tinct from the B.

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