Trypanosomes And Trypanosomiases

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' Arkhangelsky and Novikoff cured stallions of dourine by sub- cutaneous injections of sodium arsenite or cacodylic acid ' (Nocard and Leclainche). Marchal,^ veterinary officer at Constantine, states that he cured five stallions of dourine by injecting them sub- cutaneously with cacodylate of sodium in doses of i gramme in 5 c.c. water on five consecutive days, followed by five days without injections. The duration of the treatment varies ' with the resistance of the animals, and with the exten
...t to which the trypanosomes are dis- tributed throughout the body.' 1 Marchal, Rev. me'd. vcta:, April 15, 1903, p. 230, and April 15, 1904, p. 231.' DOURINE 339 [Pease,! in India, also tried the effect of injections of cacodylate of soda, but did not obtain the successful results Marchal had done.
An animal treated by Pease in this way had bouts of fever, oedema, plaques, and trypanosomes, just like an untreated animal. Pease concludes that the successful results quoted by Marchal in his second paper were probably chronic cases which were recovering spon- taneously, and in which the arsenic acted as a tonic and alterative rather than as a parasiticide.] It is naturally interesting to compare these results with those obtained by means of arsenic in the treatment of the other trypano- somiases.


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