Tuberculin in Diagnosis And Treatment

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T believe that the same principle holds good in tuberculin protein as in other proteins. We have learned that experi- mental serum diseases (hypersensitiveness or anaphylaxis) may be produced by the inoculation of small doses of serum at infrequent intervals, but that this serum disease may be pre- vented by injecting increasing doses at short intervals. I believe that this same principle applies to tuberculin therapy. The dose of tuberculin following the first should be rapidly increased with
...short intervals. It seems to me that the probable reason that we do not get a hypersensitive reaction more often in the thera- peutic employmen;t of tuberculin is because our patients have been rendered somewhat insensitive by the doses of bacillary protein which they have given themselves from their own foci of infection from time to time. When infection occurs the prob- abilities are that doses of tubercle protein are given out in rapid 94 TUBERCULIN IN DIAGNOSIS AND TREATMENT.
succession, probably almost constantly, so that, instead of a con- dition of marked hypersensitiveness developing, a condition of insensitiveness occurs.


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