Uric Acid As a Factor in the Causation of Disease; a Contribution to the Pathology of High Blood Pressure, Headache, Epilepsy, Nervousness, Mental Diseases, Asthma, Hay Fever, Paroxysmal Haemoglobinuria, Anaemia, Bright's Disease, Diabetes, Gout, Rheumati

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I would suggest that those who in future are able to estimate the amount of lead in the organs and tissues of fatal cases of plumbism, should estimate at the same time the uric acid, to see whether they are present in their combining proportions, and therefore probably as urate of lead.
Professor OUver in his interesting work on " Lead Poisoning " (p. 38), points out that during an attack of lead colic the pulse becomes hard, resistant and slow, and the urine becomes scanty and of high specific
... gravity ; the action of urate of lead will explain every fact here mentioned.
While the lead is causing retention of uric acid (its first action) the pulse is quick and soft, the capillaries are free, and the urinary water is profuse ; but later on urate of lead, which carries uric acid out of the blood and so frees the capillaries, is deposited in various organs and tissues, among others in the walls of the intestines ; here it gives rise to pain and coUc, and this quickly changes the whole condition, giving rise to the rebound or second action of lead.


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