A Text-Book of Physiological Chemistry

Cover A Text-Book of Physiological Chemistry
A Text-Book of Physiological Chemistry
Mandel, John Alfred, 1865-1929
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4 In regard to the extensive literature on the elimination of uric acid in disease we must refer to special works on internal diseases.
5 Zeitschr. f. exp. Path. u. Therap., 4.
• As it is not within the scope of this book to enter into a discussion of the numer- ous researches on this subject, we will refer to Wiener, " Die Harnsaure," Ergebnisse der Physiol., 1, Abt. 1, 1902.
Digitized by Google FORMATION OF URIC ACID. 667 At present it is considered that a direct formation of uric acid from t
...he nucleins takes place by the transformation of the purine bases of the nucleins into uric acid.
The uric acid, in so far as it is produced from nuclein bases, is in part derived from the nucleins of the destroyed cells of the body and in part from the nucleins or free purine bases introduced with the food. It is therefore possible to admit with Burian and Schur l of a double origin for the uric acid as well as the urinary purines (all purine bodies of the urine, including the uric acid), namely, an endogenous and an exogenous origin.


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